Botaone 100 – High-Purity Botulinum Toxin Type A from South Korea for Aesthetic and Medical Excellence
1. Overview & Manufactur
Botaone 10 ibotulinum toxin type A prGenetox Co., Ltd., a trusted South Korean pharmaceutical company. It is produced using the proprietary CBFC-26 strain, and is designed to meet K-GMP standards with plans for global regulatory registration (including the MFDS and FDA) in collaboration with biotech partners like Curi Bio and DreamCIS.Botaone stands out as a next-generation Korean neurotoxin, offering precision, stability, and safety for both aesthetic and therapeutic applications.
2. Composition & Formulation
100 units of purified Clostridium botulinum toxin type A, lyophilized powder
Requires reconstitution with 0.9% sodium chloride (saline) before use
Albumin-free formulation: reduces potential immunogenic response
Developed using advanced purification technology, ensuring high potency and consistency
3. Mechanism of Action
Botaone works by blocking the release of acetylcholine at the neuromuscular junction, leading to temporary relaxation of targeted muscles. This process:
Smooths dynamic facial wrinkles
Reduces muscle hypertrophy (e.g., masseter, trapezius)
Controls glandular overactivity (e.g., excessive sweating)
Alleviates certain medical conditions involving muscle spasticity or tension
4. Key Clinical Advantages
High purity, low protein content → lower risk of resistance or antibody formation
Quick onset → visible results typically within 2–4 days
Long duration → results may last 3–5 months, depending on the area and patient metabolism
Ethically tested → uses in vitro potency testing (not animal-based LD₅₀), enabling faster and more sustainable quality control
Cost-effective → competitive pricing for clinics seeking a reliable, Korean-made alternative to Western brands
5. Clinical Indications
Aesthetic Uses:
Forehead lines
Glabellar (frown) lines
Crow’s feet
Bunny lines
Chin dimpling
Masseter reduction (V-line slimming)
Platysmal bands (neck)
Therapeutic (off-label) Uses:
Hyperhidrosis (underarms, palms, soles)
TMJ tension and bruxism
Mild facial spasms
Chronic migraines
6. Dosage Guide (example, tailored to patient needs)
| Area | Units |
|---|---|
| Glabellar lines | 10–20 U |
| Forehead lines | 8–15 U |
| Crow’s feet | 6–12 U per side |
| Masseter | 25–40 U per side |
| Hyperhidrosis (axilla) | 50 U per side |
7. Storage & Handling
Store at 2–8°C; avoid freezing
Reconstitute with 2.0–2.5 mL of saline for an approximate concentration of 4–5 U per 0.1 mL
Roll gently—do not shake vigorously
Use within the manufacturer’s recommended time after dilution
8. Safety & Contraindications
Not recommended for:
Pregnant or breastfeeding patients
Individuals with neuromuscular disorders (e.g., myasthenia gravis)
Active infection at the injection site
Known allergy to botulinum toxin ingredients
Only for use by licensed healthcare professionals trained in toxin injection and facial anatomy