Xeomin® – Purified Botulinum Toxin Type A for Precision Medicine and Aesthetic Applications
1. Overview & Manufacturer
Xeomin® is a botulinum toxin type A (incobotulinumtoxinA) product manufactured by Merz Pharmaceuticals GmbH, a German pharmaceutical company known for innovation in medical aesthetics and neuroscience.
Xeomin is FDA approved in the United States, EMA approved in Europe, and used globally for both aesthetic wrinkle reduction and neurotherapy.
2. What makes Xeomin unique?
Unlike other botulinum toxins, Xeomin does not contain a complex protein—only the core neurotoxin molecule. This is often referred to as the “naked toxin.”
Key benefits of this purity:
Lower risk of antibody formation with repeated use
Reduced resistance over time
Highly stable and consistent formulation
3. Ingredients & Packaging
Available in 50 U, 100 U and 200 U vials
Lyophilized (freeze-dried) powder to be reconstituted with 0.9% NaCl (sterile saline)
Manufactured according to GMP standards in Germany with pharmaceutical grade purity
4. Mechanism of action
Xeomin works by blocking the release of acetylcholine at the neuromuscular junction. This temporarily weakens or paralyzes the muscles, resulting in:
Reducing dynamic facial wrinkles
Relaxing overactive muscles
Improving control of certain neurological conditions
Reducing sweat gland activity
5. Cosmetic Indications
FDA-approved for:
Brown furrows (wrinkles between the eyebrows)
Common off-label uses:
Forehead wrinkles
Crow’s feet
Nasal lines (wrinkles on the nose)
Chin dimples
Masticatory muscle reduction (slimming the jaw)
Neck rejuvenation (fascial banding)
6. Therapeutic Indications
FDA-approved for:
Cervical dystonia (neck spasm)
Blepharospasm (eyelid spasm)
Common off-label uses:
Hyperhidrosis (excessive sweating)
Migraines chronic headache
Spasticity (upper/lower limbs)
TMJ dysfunction and bruxism
7. Onset, Duration, and Dose
Onset: 3–5 days
Peak efficacy: 7–10 days
Duration: ~3–4 months (may vary by region and dose)
Unit concentration equivalent to Botox® (1:1 conversion)
8. Storage & Handling
Unreconstituted: Store at room temperature (up to 25°C), unlike many other toxins that require refrigeration
Reconstituted: Use within manufacturer’s recommended time frame
Handle gently—do not shake
9. Safety & Contraindications
Avoid use in:
Pregnant or lactating patients
Individuals with neuromuscular disorders (e.g., myasthenia gravis)
Patients allergic to botulinum toxin
Infection active infection at the injection site
Common side effects include local pain, bruising, temporary asymmetry or mild muscle weakness. These side effects are usually self-limiting.